When should I take Sumatriptan?

At the beginning of the headache phase, not during the aura. The earlier in the pain phase, the better the effect. Do not take preventive action!

What do I do if the first tablet doesn't work?

Do not take a second dose for the same attack – it will probably not work. Instead, you can try another painkiller (e.g. ibuprofen). At the next attack, Sumatriptan can work again.

Why do I get chest after taking?

A tightness in the chest and neck is a common, usually harmless side effect of triptans. It is rarely a sign of a heart problem. However, in case of severe or persistent complaints, you should consult a doctor.

How many times can I take Triptane?

Maximum on 10 days per month to avoid drug overuse headaches. For more frequent migraine attacks, a prophylactic treatment should be considered.

Can I combine sumatriptan with painkillers?

Yes, the combination with ibuprofen or paracetamol can improve the effectiveness. Metoclopramide against nausea is also possible. Do not combine with ergotamine or other triptans!

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What is sumatriptan?

Sumatriptan was the first triptan on the market and is still one of the most commonly prescribed migraine drugs worldwide. It has been developed specifically for the treatment of acute migraine attacks and specifically affects the mechanisms that cause migraine pain.

Unlike conventional painkillers, Sumatriptan combats migraines at the root: it narrows the extended blood vessels in the brain and inhibits the release of inflammatory substances. This not only relieves headaches, but also accompanying symptoms such as nausea and light sensitivity.

Known brand names are Imigran® and numerous generics.

Active Ingredients & Mechanism of Action

Active ingredient: Sumatriptan

Sumatriptan acts as selective serotonin receptor agonist:

Active mechanism: 1. Sumatriptan activates 5-HT1B/1D receptors in the brain Two. This leads to narrowing of enlarged cranial blood vessels 3. The release of inflammatory mediators (CGRP, substance P) is inhibited 4. The transmission of pain signals is blocked

Activation of migraine symptoms:

headache: relief due to vascular constriction
nausea: improvement through central effect
Sensitivity to light/strength
Aura: Not affected

Time:

tablet: effective after 30-60 minutes
Nose spray: Effect after 15-30 minutes
Injection: Effect after 10-15 minutes

Who is it suitable for?

Sumatriptan is suitable for:

Acute migraine attacks (with or without aura)
Cluster headache (injection)
Adults aged 18 years

Important notes:

Only after the decay of a possible aura
Not suitable for migraine prophylaxis
Not in hemiplegic or baaris migraines

Not suitable for:

cardiovascular diseases
Uncontrolled high blood pressure
Previous TIA or stroke
taking ergotamines or MAO inhibitors

Available Dosages

Tablets:

50 mg (standard dose)
100 mg (with insufficient effect)

Nasenspray:

10 mg, 20 mg

Subcutaneous injection:

6 mg (with severe attacks)

Chapters:

25 mg

Recommended dosage:

Adults: 50 mg, if required for 2 hours more 50 mg
Maximum: 300 mg in 24 hours
Treat maximum 2 attacks per week with Triptan

How to Take

Tablets:

Take in first signs of the headache phase
Suck with water
Not during the aura phase
Repeat after 2 hours if necessary

Nasenspray:

Spray into a nostril
Not breathing at the same time
Keep your head upright
In case of vomiting

Time:

Early intake is more effective
Not at Aura, but at the start of headache
When the headache is returned: second dose at the earliest after 2 hours

If first dose does not work: No second dose for the same attack! Other painkillers (e.g. ibuprofen) can be tried.

Contraindications

**Sumatriptan must not be taken at:* *

coronary heart disease (Angina pectoris, heart attack)
condition after stroke or TIA
Peripheral arterial disease
Uncontrolled high blood pressure
Heavy liver failure
Hemiplegic or Basilaris marshes
Simultaneous intake of ergotamine derivatives
MAO inhibitor therapy or less than 2 weeks after

Preview at:

Controlled high blood pressure
Cardiovascular risk factors
Liver or kidney failure
sulfonamide allergy

pregnant: Only with strict indication. Experience exists, but caution is necessary.

Possible Side Effects

Acid (1-10%):

Crawling, warmth, flush
Weakness
Squeeze
nausea (also migraine-related)
fatigue

Triptane-specific sensations (often):

tightness in chest or neck
Pressure feeling
Heavy in arms or legs
These symptoms are usually harmless!

Occasionally:

Blood pressure increase
visual disorders
No breathing

Selten:

Heart rhythm disorders
Coronary seeds
Allergic reactions
serotonin syndrome (in combination)

Important: Breast and pressure are typical triptan side effects and usually not kardial. In case of persistent or severe complaints, but seek doctor.

Interactions

Not combine with:

Ergotamine preparations (24 hours distance!)
Other triptans on the same day
MAO inhibitors (also 2 weeks after decommissioning)
Serotonine steroids (serotonin syndrome risk)

Preview at:

SSRI/SNRI antidepressants (serotonin syndrome possible)
Lithium
St. John's wort
Tryptophan

No relevant influence:

Common painkillers (Ibuprofen, Paracetamol)
Antiemetics (Metoclopramide)
Hormonal contraception

Frequently Asked Questions

Similar Medications

Rizatriptan

Zolmitriptan

Eletriptan

Is sumatriptan right for you?

A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.

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Important Notice

This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.