What is prothyride?
Prothyride is a combination preparation of levothyroxin (T4) and liothyronin (T3) for the treatment of the thyroid subfunction. It contains the two thyroid hormones in a specific ratio and is used if a pure T4 therapy is not sufficient.
Like Novothyral, prothyride is aimed at patients who still feel symptoms of subfunction despite normal TSH values under L-thyroxin monotherapy. The ratio of T4 to T3 differs from Novothyral, which permits a more differentiated dosage.
The regulation is carried out individually by the treating endocrologist or internist.
Active Ingredients & Mechanism of Action
Active ingredient: Levothyroxin (T4) / Liothyronin (T3)
Prothyride supplies both thyroid hormones:
Levothyroxine (T4):
- Long effective prohormone
- Converts to T3 in tissue
- Provides basic supply with thyroid hormone
Liothyronine (T3):
- Biologically active form
- Faster action
- Shorter half-life (approx. 24 hours)
Rational combination: In some patients, the conversion of T4 to T3 in the tissue is restricted (e.g. by genetic variants of the deiodinase-2-enzyme). The direct T3-Gabe can in these cases improve the symptoms.
Who is it suitable for?
Prothyride can be suitable for:
- Patients with hypothyroidism and inadequate response to L-thyroxine
- For proven or suspected limited T4-T3 conversion
- In medical consideration as an alternative to Novothyral
Standard therapy remains L-thyroxin mono.
Not suitable for:
- coronary heart disease
- Heart rhythm disorders
- Osteoporosis (Preview)
- Older patients with cardiovascular risk factors
Available Dosages
Available strength:
- 100 mcg Levothyroxin + 10 mcg Liothyronin per tablet
Dosing:
- Individually according to laboratory findings (TSH, fT3, fT4)
- Mostly 1 tablet per day
- Close checks on therapy conversion
How to Take
Intake:
- Morning, sober, 30 minutes before breakfast
- With water (no coffee, no milk)
- Every day at the same time
Default:
- 2 h to calcium, iron, magnesium, antazida
- 4-5 h to cholestyramine
Controls:
- TSH, fT3 and fT4 regularly determine
- Especially at the beginning close-mesh (all 4-6 weeks)
Contraindications
**Prothyride must not be taken at:* *
- Untreated secondary bark insufficiency
- Acute heart attack, acute myocardialitis
- thyroid hyperfunction
Special caution (T3-share):
- coronary heart disease
- Heart rhythm disorders, atrial dimmers
- Older patients
- osteoporosis
pregnant: thyroid hormones are essential. If necessary, consider conversion to pure T4. Medical care required.
Possible Side Effects
For correct dosage: No side effects expected.
For overdose (particularly T3):
- cardiac arrhythmias
- Internal unrest, nervousness
- Sweating, thermal incompatibility
- trembling, sleep disorders
- diarrhea, weight loss
Long-term risks for overdose:
- osteoporosis
- Hopeful dimmers
Interactions
Like L-thyroxin:
- Calcium, Iron, Magnesium – Reduced absorption
- Cholestyramine – binds thyroid hormones
- estrogens – increased T4
- Anticoagulants – enhanced effect
Frequently Asked Questions
Similar Medications
Is prothyride right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.