What is Onbrez Breezhaler?
Onbrez Breezhaler is an ultra-long-active beta-2-agonist (ultra-LABA) with the active ingredient Indacaterol. It is inhaled once a day and offers a 24-hour bronchodilation at COPD.
Indacaterol combines the advantages of rapid action (within 5 minutes) with a 24-hour duration of action. Like Seebri, Onbrez is inhaled via the Breezhaler (capsule inhaler).
Onbrez is manufactured by Novartis. Indacaterol is also part of the combination preparation Ultibro (with glycopyrronium).
Active Ingredients & Mechanism of Action
Active ingredient: Indacaterolmaleat
Indacaterol acts as an ultra-long-active beta-2-agonist:
Active mechanism:
- Activated beta-2-adrenoceptors
- Increases intracellular cAMP levels
- Relax the bronchial muscle
- Extends the airways
Special features:
- Fast action (5 minutes)
- Ultra-long duration (24 hours)
- High intrinsic activity
- Only once a day
Time:
- Effect: 5 minutes
- Maximum effect: 2-4 hours
- duration of action: 24 hours
Who is it suitable for?
Onbrez Breezhaler is suitable for:
- COPD continuous therapy in adults
- As a long-acting bronchodilatator
- Once daily therapy
Advantages:
- Once a day
- Fast and slow-acting
- Breezhaler with acoustic feedback
Not suitable:
- For asthma (not approved as monotherapy!)
- As an emergency medication
- For children and young people
Available Dosages
Onbrez Breezhaler:
- 150 μg indacaterol per capsule
- 300 μg Indacaterol per capsule (higher dose)
Dosing:
- Recommended: 150 μg once a day
- If required, 300 μg once a day
- Inhale 1 capsule once a day
** Don't swallow capsules! Always inhale at the same time of day.
How to Take
Breezhaler (capsule inhaler): 1. Remove cap, flap mouthpiece Two. Insert capsule 3. Close mouthpiece, press side buttons 4. Deep exhalation Five. enclose mouthpiece, deep breath 6. Capsule must surge 7. Keep breath 8. For residual powder: inhale again
Hust after inhalation: A short cough after inhalation is common and normal in Indacaterol. This does not impair the effectiveness.
Contraindications
Do not apply at:
- hypersensitivity to indacaterol or lactose
- Asthma as monotherapy (without ICS!)
Preview at:
- Heavy cardiovascular diseases
- QT extension
- Hyperthyroidism
- Diabetes mellitus
- Hypokaliemia
pregnant: Only with clear indication.
Style time: Not recommended.
Possible Side Effects
Acid (1-10%):
- Husten nach Inhalation (harmlos)
- Nasopharyngitis
- Headaches
- infections of the upper respiratory tract
Occasionally:
- Heart palp
- Tremor
- Muscle cramps
- Mouth dryness
- Squeeze
Selten:
- Heart rhythm disorders
- Paradox bronchospasmus
- Hypokaliemia
** The cough after inhalation is typical of indacaterol and does not affect the effectiveness.
Interactions
Reactions:
- Betablockers – can eliminate indacaterol action
- QT-extending medication
- MAO inhibitors, tricyclic antidepressants
- Potassium sinking drugs
Ingenious combination:
- With LAMA (e.g. glycopyrronium = Ultibro)
- With ICS as needed
Frequently Asked Questions
Similar Medications
Is Onbrez Breezhaler right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.