What is Estramon conti?
Estramon conti is a combined transdermal plaster that releases both estradiol (estrogen) and norethisterone acetate (stagnation) over the skin. It is used for the treatment of alternating-year complaints in postmenopausal women with intact uterus.
The great advantage of the patch: both hormones are absorbed via the skin and bypass the liver (no first pass effect). This leads to a lower risk of thrombosis than in oral preparations and a more uniform release of hormones.
The plaster is changed 2x per week and is designed as a continuous combination therapy (bleed-free).
Active Ingredients & Mechanism of Action
Active ingredient: Estradiol 50 µg/24h, Norethisteronacetat 170 µg/24h
Transdermal hormone charge over 3-4 days:
Estradiol:
- Is absorbed into the blood circulation via the skin
- equals the oestrogen deficiency
- Relieves heat flashes and sweat breaks
- Improves vaginal health
Norethisterone acetate:
- Protects the cervical mucosa
- Prevents endometrium hyperplasia
- Continuous delivery = no bleeding
Advantages of transdermal administration:
- Resurrection of the liver
- Lower risk of thrombosis
- Uniform hormone levels
- Less influence on blood fats and coagulation factors
Who is it suitable for?
Estramon conti is suitable for:
- Postmenopausal women (last bleeding > 12 months)
- Women with intact uterus
- Women with increased risk of thrombosis (perversely preferred)
- Women who want to avoid tablets
Advantages:
- Change only 2x per week
- bleeding-free
- Lower risk of thrombosis as tablets
- Both hormones in a plaster
Not suitable:
- In contraindications against HRT
- Incompatibility with plaster
- Perimenopausal women
Available Dosages
Estramon conti patch:
- Estradiol 50 μg/24h + NETA 170 μg/24h
- 1 patch every 3-4 days (2x per week)
- Throughout without a break
Plant change days:
- Choose festive days (e.g. Monday and Thursday)
- Always change the same day
How to Take
Pflaster on glue: 1. Remove old pavement (if available) Two. Clean, dry, unhaired skin 3. Preferred: lower belly, hip, buttocks 4. Pull off protective film, stick on plaster Five. 10 seconds tight 6. Adhesive site regularly change
Important notes:
- Don't stick to the chest!
- Not on irritated or injured skin
- When bathing/showing, the plaster can remain
- Not on the same place within 7 days
Contraindications
Do not apply at:
- Breast cancer
- estrogen-dependent tumors
- Unexplained vaginal bleeding
- Active thrombosis
- Heavy liver disease
Preview at:
- Thrombosis risk
- Migraine
- uterus myomas
- Endometriosis
- Diabetes, high blood pressure
Pregnant period: Contraindicated.
Possible Side Effects
Acid (1-10%):
- Skin reactions at the adhesive site
- Breast tensions
- Headaches
- Lubrication (in the beginning)
Occasionally:
- Mood changes
- nausea
- Blowing
- Weight gain
Selten:
- Thromboemboly (lower than oral HRT)
- bile stone diseases
** Skin reactions can be minimized by regularly changing the adhesive spot.
Interactions
Reactions:
- CYP3A4 inductors – possibly reduced effect
- Less interactions than oral HRT
** Transdermal application bypasses the first pass effect and therefore shows fewer interactions.
Frequently Asked Questions
Similar Medications
Is Estramon conti right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.