What is DoloPosterine® (Bufexamac/Lidocain)?
DoloPosterine® is a prescription combination preparation for treating hemorrhoids containing NO corticosteroid. Instead, Bufexamac – a non-steroid anti-inflammatory drug (NSAID) – is combined with the local anesthetic Lidocain.
The advantage over corticosteroid-containing preparations, such as Doloproct®, is that bufexamac does not cause any skin atrophiic (skin dilution) and can therefore in principle also be used a little longer.
DoloPosterine® is available as rectal cream and as supper. It is used in hemorrhoids, analeczema and analfissures if a cortisone-free treatment is preferred.
**Bufexamac has been restricted by EMA in some forms of administration (formerly). The rectal application is still available in Germany.
Active Ingredients & Mechanism of Action
Active ingredient: Bufexamac / Lidocainhydrochlorid
DoloPosterine® combines two active ingredients:
1. Bufexamac (non-steroidal anti-inflammatory):
- inhibits cyclooxygenase (COX) locally
- Reduces prostaglandin synthesis in the inflammatory mucosa
- Anti-inflammatory action without cortisone
- No skin atrophy for longer use
- Swelling and irritating effect
2. Lidocain (local anesthetic):
- Immediate local anesthesia
- Blocks sodium channels of pain fibres
- relieves pain, burning and itching
- Effects within minutes
- duration of action: 1–2 hours
Combined action: Lidocain provides immediate pain relief, while Bufexamac combats the underlying inflammation – without the disadvantages of a corticosteroid.
Who is it suitable for?
DoloPosterine® is suitable for:
- Hemorrhoids degree I and II
- Analeczema
- Superficial anal fissures
- Proctitis
Especially recommended at:
- Patients who do not want or are allowed to use cortisone
- Repeated hemorrhoidal complaints (no atrophie risk)
- If Doloproct® is not suitable due to cortisone side effects
- Mild to moderate complaints
Not suitable:
- Heavy hemorrhoids (Grade III–IV)
- hypersensitivity to Bufexamac or Lidocain
- Infections in the field of application
- Known contact allergy to Bufexamac
Available Dosages
Rectal cream:
- apply 2–3 × daily thin
- In case of acute complaints, initially more frequently
- After improvement: 1–2 × daily
Chapters:
- 1 cups 2–3 × daily introduce rectal
- After improvement: 1 × daily
Application duration:
- Recommended: 1–2 weeks
- Maximum 3–4 weeks without medical rejuvenation
- No strict time limit as recommended for corticosteroid preparations, but medical control
Available dosage forms:
- DoloPosterine® rectal cream (with applicator)
- DoloPosterine® cups
How to Take
Rectal cream:
- Clean and dry anal region before application
- apply thin layer (outside)
- For inner hemorrhoids: Use applicator
- Wash hands after application
Chapters:
- preferably insert after the chair
- Insert the cups with moistened fingers
- Rounded end first
Important notes:
- When used for the first time on allergic reaction
- If complaints worsen or do not improve after 1 week: Visit doctor
- Not with bleeding hemorrhoids without medical clarification
- Latex condoms can be damaged by the ointment base
General measures:
- High diet and sufficient drinking
- Avoid heavy pressing in chairs
- Softly clean anal region after stool
Contraindications
**DoloPosterine® must not be used at:* *
- hypersensitivity to Bufexamac or Lidocain
- Known contact allergy to Bufexamac
- Virus infections in the field of application
- Mushroom infections in application area
Preview at:
- Allergic disposition (Bufexamac can trigger contact sensitization)
- Neurodermitis / atopic eczema (increased allergization risk)
- Large-surface or long-lasting application
pregnant and breastfeeding: No sufficient data. Apply only after medical consultation. The systemic uptake in rectal application is low.
**Note to Bufexamac:* * Bufexamac can trigger contact allergy in rare cases. With increasing redness, itching or aggravation of complaints, the application should be terminated immediately and a doctor should be consulted.
Possible Side Effects
** Occasionally (0.1-1 %):* *
- Burning at the application site
- Local itching
- Skin redness
Selten:
- Contact allergic reaction to Bufexamac
- Contact dermatitis (can be expressed as a worsening of symptoms)
- Allergic reaction to Lidocain (very rare)
Note about contact allergy: Bufexamac has a certain potential for contact sensitization. This was the reason for limitations in this application in some countries. The risk of rectal application is lower. If the symptoms worsen under the treatment, a contact allergy could be present – immediately stop and consult doctor.
Advantage to corticosteroid preparations: No skin atrophies, no teleangiectasis, no strias even with a little longer use.
Interactions
Clinical interactions: In the case of rectal application, systemic interactions are practically excluded.
Theoretically possible:
- Other local anaesthetics: additives
- Latex condoms: can be damaged by the ointment base
** The systemic inclusion of bufexamac and lidocain from rectal use is too low for clinically relevant drug interactions.
Frequently Asked Questions
Similar Medications
Is DoloPosterine® (Bufexamac/Lidocain) right for you?
A licensed doctor will review your information and issue a prescription if suitable. Discreet and secure.
Important Notice
This information does not replace medical advice. If you have questions about your health or the suitability of this medication, please consult a doctor. Read the package leaflet before use.